RESOURCES

Voltage-gated sodium channels (Na_vs) play a crucial electrical signaling role in neurons.

hERG block potency is widely used to calculate a drug’s safety margin against its torsadogenic potential.

Automated patch clamp (APC) instruments enable efficient evaluation of electrophysiologic effects of drugs on human cardiac currents in heterologous expression systems.

Several Bevacizumab products are approved for clinical use, with many others in late-stage clinical development worldwide.

Toll-like receptors (TLRs) are the pattern recognition receptors, which are activated by foreign and host molecules in order to initiate the immune response.

Phenotypic drug discovery (PDD) uses biological systems directly for new drug screening.

Fibrotic disease is a major cause of mortality worldwide, with fibrosis arising from prolonged inflammation and aberrant extracellular matrix dynamics.

The development of high-throughput screening methodologies may decrease the need for laboratory animals for toxicity testing.

Metabolites produced in the human gut are known modulators of host immunity.

Use of a rapid human primary cell-based disease screening model to compare next generation products to combustible cigarettes.

Screening in phenotypic assays is an important strategy for the discovery of innovative drugs and novel targets.

The study of innate immunity and its link to inflammation and host defense encompasses diverse areas of biology, ranging from genetics and biophysics to signal transduction and physiology.