MCH1 Human Melanin-Conc. Hormone GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR

Background Information:

The human melanin-concentrating hormone receptor is a member of the G protein coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The melanin-concentrating hormone receptor 1 (MCH1) binds the melanin concentrating hormone, a cyclic orexinogenic peptide. MCH1 is mostly expressed in the central nervous system and plays an important role in feeding behavior. MCH1 has also been implicated in regulating emotion, stress and motivation.

Family:

GPCR

Sub Family:

Melanin-Concentrating Hormone

Class:

Class A

Protein Name:

MCH1

Uniprot Number:

Q99705

Protein Aliases:

MCH-R1|MCHR-1|G-protein coupled receptor 24|MCH-1R|MCH1R|MCHR|SLC-1|Somatostatin receptor-like protein

Gene Name:

MCHR1

Gene ID:

2847

Gene Aliases:

SLC1|MCH1R

Accession Number:

NM_005297

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1