OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
The cysteinyl leukotrienes (LTC4, LTD4, LTE4) are products of arachidonic acid metabolism and are released from various cells, including mast cells and eosinophils. These eicosanoids bind to cysteinyl leukotriene (CysLT) receptors. CysLT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. CysLT type-1 (CysLT1) receptor is found in the human airway and on other pro-inflammatory cells.
Family:
GPCR
Sub Family:
Leukotriene
Class:
Class A
Protein Name:
CysLT1
Uniprot Number:
Q9Y271
Gene Name:
CYSLTR1
Gene ID:
10800
Gene Aliases:
CysLT1|CysLT(1)|CYSLT1R
Accession Number:
NM_006639
Organism:
Human
Construct Details:
Recombinant
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Antagonist
Detection Method:
Fluorimetry
Measured Response:
Fluorescence
Testing Information
Incubation:
RT
Control Inhibitor:
MK 571
Control Activator:
LTD4 (0.1 nM)
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 70 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Adverse / Beneficial Action:
Cysteinyl leukotriene antagonists may be therapeutically useful in the treatment of allergic-induced inflammation associated with asthma, rhinitis, pruritis, etc.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
CysLT1 Human Leukotriene GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item: 1383
CysLT1 Human Leukotriene GPCR Cell Based Agonist & Antagonist Calcium Flux LeadHunter Assay - FR
Item: G024
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