CB1 Human Cannabinoid GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR

Background Information:

Two subtypes of the G-protein coupled cannabinoid receptor, CB1 and CB2, have been identified. CB1 couples to a pertussis-toxin sensitive G-protein to regulate Ca2+ currents, to activate inward rectifying K+ channels, and to activate MAP Kinases. High densities of CB1 receptors within the caudate-putamen, hippocampus and neocortex, suggests involvement in motor control, learning, and memory and cognitive function. Outside the CNS, CB1 expression is found in the testes, endothelial cells and ileum longitudinal smooth muscle.

Family:

GPCR

Sub Family:

Cannabinoid

Class:

Class A

Protein Name:

CB1

Uniprot Number:

P21554

Protein Aliases:

CB1|CANN6

Gene Name:

CNR1

Gene ID:

1268

Gene Aliases:

CB1K5|CB-R|CB1|CANN6|CB1A

Accession Number:

XM_017010238

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1