NOP (ORL1) Human Opioid GPCR Cell Based Agonist cAMP LeadHunter Assay - FR

Background Information:

Orphanin (N/OFG, NOP) receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The neuropeptide nociceptin/Orphanin FQ (N/OFQ) was recently identified as the endogenous ligand for the opioid receptor-like (ORL1) receptor. Orphanin ORL1 receptors are found primarily, but not entirely, in the central nervous system.

Family:

GPCR

Sub Family:

Opioid

Class:

Class A

Protein Name:

NOP (ORL1)

Uniprot Number:

P41146

Protein Aliases:

LC132 receptor-like|orphanin FQ receptor|kappa3-related opioid receptor|nociceptin/orphanin FQ receptor

Gene Name:

OPRL1

Gene ID:

4987

Gene Aliases:

NOCIR|ORL1|OOR|KOR-3|NOPr

Accession Number:

NM_182647

Organism:

Human

Construct Details:

Recombinant

Cell Type:

CHO-K1