CCK2 (CCKB) Human Cholecystokinin GPCR Cell Based Agonist IP1 LeadHunter Assay - TW

Background Information:

Cholecystokinin receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Cholecystokinin CCK₂ receptors are widely distributed in the brain, with highest concentrations in the striatum, cerebral cortex and limbic system, but can also be found in the stomach. CCK₂ receptor agonism may enhance anxiety and gastric acid secretion. CCK₂ receptor antagonism may impair memory.

Family:

GPCR

Sub Family:

Cholecystokinin

Class:

Class A

Protein Name:

CCK2 (CCKB)

Uniprot Number:

P32239

Protein Aliases:

CCK-BR|Cholecystokinin-2 receptor|CCK2-R

Gene Name:

CCKBR

Gene ID:

887

Gene Aliases:

CCKRB

Accession Number:

NM_176875

Organism:

Human

Construct Details:

Full Length, Recombinant

Cell Type:

1321N1