5-HT6 Human Serotonin GPCR Cell Based Agonist cAMP LeadHunter Assay - TW

Background Information:

Serotonin (5-hydroxytryptamine, 5-HT) is one of the well-known examples of a neurotransmitter that mediates a wide variety of physiological effects, including peripheral and central actions. At least four classes of 5-HT receptors have been distinguished pharmacologically, reflecting the second messenger system to which the receptor is coupled. The subfamily of 5-HT₁ and 5-HT₅ interacts negatively with adenylyl cyclase. The second subfamily of 5-HT₂ is coupled to the activation of the phospholipase C. The third, 5-HT₃, is a ligand-gated ion channel and the last subfamily, including 5-HT₄, 5-HT₆, and 5-HT₇ activates adenylyl cyclase to increase intracellular cAMP.

Family:

GPCR

Sub Family:

Serotonin

Class:

Class A

Protein Name:

5-HT6

Uniprot Number:

P50406

Protein Aliases:

5-HT6|Serotonin receptor 6

Gene Name:

HTR6

Gene ID:

3362

Gene Aliases:

5-HT6|5-HT6R

Accession Number:

NM_000871

Organism:

Human

Construct Details:

Full Length, Recombinant

Cell Type:

HeLa