5-HT5A Human Serotonin GPCR Cell Based Agonist & Antagonist Calcium Flux LeadHunter Assay - TW

Background Information:

Serotonin 5-HT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins with the exception of the 5-HT3 subtype, which belongs to the ligand gated cation superfamily of receptors. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Serotonin 5-HT5A receptors are widely present in the central nervous system but not or minimally in peripheral tissues. The 5-HT5A receptor class couples preferentially to GS to promote cAMP formation. Serotonin 5-HT5A receptor agonism may be hallucinatory and alter circadian rhythms.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

Serotonin

Class:

Class A

Protein Name:

5-HT5A

Uniprot Number:

P47898

Protein Aliases:

5-HT-5A|5-HT5A|Serotonin receptor 5A

Gene Name:

HTR5A

Gene ID:

3361

Gene Aliases:

5-HT5A

Accession Number:

NM_024012

Organism:

Human

Construct Details:

Full Length, Recombinant

Cell Type:

CHO-K1