NET Human Norepinephrine Transporter Functional Antagonist Uptake LeadHunter Assay - FR

Background Information:

The actions of several neurotransmitters, including norepinephrine, are regulated through their rapid uptake and clearance from synaptic junctions by plasma membrane transport proteins. The norepinephrine transporter in central adrenergic neurones is responsible for the recovery of up to 90 percent of released transmitter. The monoamine transporters are high affinity targets for a number of psychoactive agents such as cocaine, amphetamine, and antidepressants. These agents, by blocking transporters and consequently preventing neuronal uptake, elevate levels of extracellular neurotransmitter concentrations in both the central and peripheral nervous systems, contributing to their behavioral and autonomic effects.

Family:

Transporter

Sub Family:

SLC6 / Monoamine

Class:

SLC

Protein Name:

NET

Uniprot Number:

P23975

Protein Aliases:

norepinephrine transporter

Gene Name:

SLC6A2

Gene ID:

6530

Gene Aliases:

NET

Organism:

Human

Cell Type:

CHO