VIP1 (VPAC1) Human VIP and PACAP GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
VIP1 (VPAC1) receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The VIP receptor family includes receptors for pituitary adenylate cyclase-activating polypeptide (PACAP), secretin, glucagon-like peptide-1 (GLP-1), calcitonin, parathyroid hormone and growth hormone-releasing factor, which are coupled preferentially to GaS to stimulate adenylate cyclase and increase cAMP levels. VIP1 receptors are widely distributed in the central nervous system, in peripheral tissues and in T lymphocytes.
Family:
GPCR
Sub Family:
VIP and PACAP
Class:
Class B
Protein Name:
VIP1 (VPAC1)
Uniprot Number:
P32241
Protein Aliases:
PVR2|HVR1|RDC1|VIP and PACAP receptor 1|PACAP-R2|pituitary adenylate cyclase-activating polypeptide type II receptor|VIP-R1
Gene Name:
VIPR1
Gene ID:
7433
Gene Aliases:
VPAC1|RDC1|HVR1|VPAC1R
Accession Number:
NM_004624
Organism:
Human
Cell Type:
HT-29
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist
Detection Method:
HTRF
Testing Information
Incubation:
10 min at 37°C
Control Activator:
VIP
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 60 µl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing. 2) Dose Response: 90 µl of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Adverse / Beneficial Action:
VIP1 receptor agonism may reduce immune mediated brain, pulmonary and gastrointestinal inflammation, gastrointestinal transit and pulmonary hypertension and cause vasodilation.
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
VIP1 (VPAC1) Human VIP and PACAP GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item: 157
VIP1 (VPAC1) Human VIP and PACAP GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item: 515
VIP1 (VPAC1) Human VIP and PACAP GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - FR
Item: G101
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