OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Serotonin 5-HT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins with the exception of the 5-HT3 subtype, which belongs to the ligand gated cation superfamily of receptors. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The 5-HT1 receptor class couples preferentially to Gi/Go to inhibit cAMP formation. Serotonin 5-HT1A receptors are widely distributed in the central nervous system as well as in the periphery.
Family:
GPCR
Sub Family:
Serotonin
Class:
Class A
Protein Name:
5-HT1A
Uniprot Number:
P08908
Protein Aliases:
5-HT1A|G-21|Serotonin receptor 1A
Gene Name:
HTR1A
Gene ID:
3350
Gene Aliases:
ADRB2RL1|ADRBRL1
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist
Testing Information
Test Sample Requirements:
300uL of a 1000X stock based on the top or final concentration being tested
Turnaround Time
Standard:
20 Business Days
Service Scheduling Note:
Eurofins DiscoverX will make reasonable efforts to deliver screening data within (20) business days from the start date of the scheduled assay service provided that Materials and required documentation are received prior to run date.
Clinical Relevance
Adverse / Beneficial Action:
Serotonin 5-HT1A receptor agonism may be antidepressant, anxiolytic, antipsychotic, reduce traumatic brain injury and emesis. Receptor antagonism may be anxiogenic and contribute to depression and suicide.
Additional Information
Brand:
SafetyScreen
Testing Location:
USA - San Diego, CA
Questions? Contact Us
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