5-HT7 Human Serotonin GPCR Cell Based Antagonist cAMP LeadHunter Assay - US

Background Information:

Serotonin 5-HT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins with the exception of the 5-HT3 subtype, which belongs to the ligand gated cation superfamily of receptors. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Serotonin 5-HT7 receptors are present in the central nervous system and peripheral tissues. The 5-HT7 receptor class couples preferentially to GS to promote cAMP formation.

cAMP Hunter™ Gs cell lines overexpress naturally Gs coupled, wild type GPCRs and are designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Serotonin

Class:

Class A

Coupling:

Gs

Protein Name:

5-HT7

Uniprot Number:

P34969

Protein Aliases:

5-HT7|5-HT-X|Serotonin receptor 7

Gene Name:

HTR7

Gene ID:

3363

Gene Aliases:

5-HT7

Accession Number:

NM_000872

Organism:

Human

Cell Type:

DLD1