OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
IL-1β is used to induce cardiovascular inflammation and stimulate HUVECs for secretion of inflammatory agents MCP-1, IL-6, IL-8, ICAM-1, VCAM-1, and E-Selectin. Inhibition by client compound is reported in pg/mL for the strength of the response.
Organism:
Human
Construct Details:
Endogenous
Cell Type:
HUVEC
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Antagonist
Detection Method:
Luminex
Measured Response:
Fluorescence
Testing Information
Incubation:
24 hrs at
Control Inhibitor:
Dexamethasone
Control Activator:
IL-1β
Test Sample Requirements:
Minimum for 1) Screen: 25 μl of 10 mM stock -OR- 1 mg (pre-weighed). 2) Dose Response: 60 μl of 10 mM stock -OR- 1 mg (pre-weighed).
Turnaround Time
Standard:
20 Business Days
Clinical Relevance
Therapeutic Area:
Inflammation/Allergy
Additional Information
Brand:
Panlabs
Testing Location:
USA - St Charles, MO
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