D3 Human Dopamine GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - FR
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Five subtypes of dopamine receptors, D1, D2, D3, D4 and D5, were identified on the basis of pharmacological or biochemical criteria. Dopamine receptors have been classified into either the D1-like (D1, D1B, and D5) or D2-like (D2, D3, and D4). The selective D3 receptor involvement in regulating cognition and awareness states, and not generalized motor coordination, have potential therapeutic utility in treating attention deficit disorders.
No. of Assays on Panel:
2
Assays on Panel:
Family
GPCR
Name
D3 Human Dopamine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item
683
Protein
D3
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
D3 Human Dopamine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item
684
Protein
D3
Organism
Human
Assay Sub Type
Cell Based
Family:
GPCR
Sub Family:
Dopamine
Class:
Class A
Protein Name:
D3
Uniprot Number:
P35462
Gene Name:
DRD3
Gene ID:
1814
Organism:
Human
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist & Antagonist
Detection Method:
HTRF
Testing Information
Incubation:
30 min at 37°C
Control Activator:
dopamine (10 nM)
Test Concentration / Dose:
Eurofins will provide IC/EC50 calculation if 5 or more concentrations are selected.
Test Sample Requirements:
Minimum for 1) Screen: 60 µL of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM finµL testing. 2) Dose Response: 90 µL of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
16
Turnaround Time
Standard:
15 Business Days
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain
Adverse / Beneficial Action:
Dopamine D3 receptor antagonist may be useful in treatment of psychosis, possibly without causing tardive dyskinesia, attention deficit disorder and hyperprolactemia; receptor antagonism has also been reported to attenuate cocaine addiction
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
D3 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item: 48
D3 Human Dopamine GPCR Cell Based Agonist cAMP LeadHunter Assay - FR
Item: 683
D3 Human Dopamine GPCR Cell Based Antagonist cAMP LeadHunter Assay - FR
Item: 684
Questions? Contact Us
You can easily get in touch with a Eurofins Discovery Expert or get help from our Customer Service team. Reach out with questions, or to discuss your specific discovery challenges.
