5-HT7 Human Serotonin GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - FR

Background Information:

Serotonin 5-HT receptors belong to the superfamily of G protein-coupled seven transmembrane proteins with the exception of the 5-HT3 subtype, which belongs to the ligand gated cation superfamily of receptors. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Serotonin 5-HT7 receptors are present in the central nervous system and peripheral tissues. The 5-HT7 receptor class couples preferentially to GS to promote cAMP formation.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

Serotonin

Class:

Class A

Protein Name:

5-HT7

Uniprot Number:

P34969

Protein Aliases:

5-HT7|5-HT-X|Serotonin receptor 7

Gene Name:

HTR7

Gene ID:

3363

Gene Aliases:

5-HT7

Organism:

Human

Cell Type:

CHO-K1