OX2 Human Orexin GPCR Cell Based Agonist & Antagonist Calcium Flux LeadHunter Assay - FR

Background Information:

Orexins, also called hypocretins, are the common names given to a pair of highly excititory neuropeptide hormone. Two highly-related peptides (Orexin A and B) are produced by cleavage of a single precursor protein. Both peptides bind to two G-protein coupled receptors, orexin-1 (OX1) and orexin-2 (OX2). The orexin receptors are located predominantly in the hypothalamus and locus coeruleus, but are also found elsewhere in the CNS. The orexins have been linked to a range of physiological functions including the control of feeding and energy metabolism, modulation of neuroendocrine function, and regulation of the sleep-wake cycle. Orexin OX2 receptor antagonism may be useful for the treatment of insomnia and obesity.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

Orexin

Class:

Class A

Protein Name:

OX2

Uniprot Number:

O43614

Protein Aliases:

orexin receptor 2

Gene Name:

HCRTR2

Gene ID:

3062

Gene Aliases:

OX2R

Organism:

Human

Cell Type:

HEK293