PAC1 (PACAP) Human VIP and PACAP GPCR Cell Based Agonist & Antagonist cAMP LeadHunter Assay - FR

Background Information:

Pituitary adenylate cyclase–activating polypeptide (PACAP) is a ubiquitous neuropeptide of the vasoactive intestinal peptide (VIP) family. PACAP exists in 2 forms; one as a 38 aa peptide (PACAP-38) and a C-terminally truncated, 27aa form of the peptide (PACAP-27). PACAP type I receptor has high affinity for both PACAP peptides and is expressed predominantly in the CNS (most abundantly in the olfactory bulb, thalamus, hypothalamus, the dentate gyrus of the hippocampus and in granule cells of the cerebellum. Studies on PAC1 receptor knockout mice point to a role for presynaptic PAC1-mediated signalling at the mossy fibre synapse in long-term potentiation (LTP) and hippocampus-dependent associative learning. The PAC1 receptor is also expressed in brain areas which have been implicated in the emotional control of behavior, such as the amygdala, the hypothalamus, the locus coeruleus and the periaqueductal grey. Consistent with this, mice with a ubiquitous but not with a forebrain-specific deletion of the PAC1 receptor exhibited elevated locomotor activity and strongly reduced anxiety-like behavior. It is also expressed on pancreatic β-cells and has been implicated in the control of pancreatic insulin secretion.

No. of Assays on Panel:

2

Family:

GPCR

Sub Family:

VIP and PACAP

Class:

Class B

Protein Name:

PAC1 (PACAP)

Uniprot Number:

P41586

Protein Aliases:

PACAP-R-1|PACAP-R1|PACAP receptor 1

Gene Name:

ADCYAP1R1

Gene ID:

117

Gene Aliases:

PAC1|PACAPR|PAC1R

Organism:

Human

Cell Type:

CHO-K1