OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Assess abuse potential of your compounds with FDA related in vitro SafetyScreen panel and assays. Compounds with pharmacological or structural similarity to current controlled substance or that affect CNS are candidates for Drug Abuse Potential assessment (2017 FDA Draft guidance).
To evaluate whether your new molecular entities drug abuse potential, Eurofins Discovery provides robust in vitro SafetyScreen panel and binding assay services (GPCRs, Transporters, Ion channels and Nuclear receptors) that address FDA requirements in one single dedicated panel, the Drug Abuse Potential Panel P293.
No. of Assays on Panel:
44
Assays on Panel:
Family
GPCR
Name
5-HT2C Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1003
Protein
5-HT2C
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
114
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
118
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (Non-Selective) Rat Ion Channel [3H] TCP Binding LeadHunter Assay - FR
Item
124
Protein
NMDA(PCP site)
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
13
Protein
alpha2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
131
Protein
5-HT1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D2S Human Dopamine GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1322
Protein
D2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2B Human Serotonin GPCR [125I](±)DOI Binding Agonist Radioligand LeadHunter Assay - FR
Item
1333
Protein
5-HT2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2B Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
1344
Protein
alpha2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2C Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
16
Protein
alpha2C
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav2.2 (N-type) Rat Calcium Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
164
Protein
Cav2.2 (N-type)
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
18
Protein
beta1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
OX1 Human Orexin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1987
Protein
OX1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
OX2 Human Orexin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1988
Protein
OX2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
20
Protein
beta2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
2338
Protein
alpha1A
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (alpha7) Human Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
3010
Protein
nAChR
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (alpha4/beta2) Human Ion Channel Binding Agonist Radioligand LeadHunter Assay - FR
Item
3029
Protein
nAChR
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel [3H] Muscimol Binding Agonist Radioligand LeadHunter Assay - FR
Item
3051
Protein
GABAA
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
NET Human Norepinephrine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
355
Protein
NET
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
37
Protein
CB2
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
5-HT3 Human Serotonin Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
411
Protein
5-HT3A
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
SERT Human Serotonin Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
439
Protein
SERT
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D1 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
44
Protein
D1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4461
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel [3H] Flunitrazepam Binding Agonist Radioligand LeadHunter Assay - FR
Item
4518
Protein
GABAA(BZD site)
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
GR Human Glucocorticoid NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
469
Protein
GR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4708
Protein
CB1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
471
Protein
5-HT2A
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (Non-Selective) Rat Ion Channel Glycine (Strychnine-Insensitive) Mass Spectrometry Binding LeadHunter Assay - FR
Item
5043
Protein
NMDA(strychine-insensitive site)
Organism
Rat
Assay Sub Type
Binding
Family
Transporter
Name
DAT Human Dopamine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
52
Protein
DAT
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GluK2 Human Ion Channel [3H] Kainic acid Binding LeadHunter Assay - FR
Item
5379
Protein
Kainate
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
ERalpha Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
5484
Protein
ERalpha
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Sodium Channel Site2 (Non-selective) Rat Ion Channel Batrachotoxin Mass Spectrometry Binding LeadHunter Assay - FR
Item
5572
Protein
Nav1.5
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel Picrotoxinin Mass Spectrometry Binding Antagonist Ligand LeadHunter Assay - FR
Item
5666
Protein
GABAA
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
GAT1 Human GABA Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
5773
Protein
GAT-1
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (NMDA, NR1/NR2A) Human Ion Channel [3H] CGP-39653 Binding LeadHunter Assay - FR
Item
5875
Protein
GluN1 / GluN2A
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (AMPA, Non-Selective) Rat Ion Channel [3H] AMPA Binding LeadHunter Assay - FR
Item
64
Protein
AMPA
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
91
Protein
M1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
93
Protein
M2
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
AR Human Androgen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
933
Protein
AR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
95
Protein
M3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M4 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
96
Protein
M4
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M5 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
97
Protein
M5
Organism
Human
Assay Sub Type
Binding
Testing Information
Test Sample Requirements:
Minimum for Screen: 105 μl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing.
Turnaround Time
Standard:
15 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
France - Celle L'Evescault
Questions? Contact Us
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