OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
The SafetyScreen CNS Panel is an in vitro CNS safety panel that provides a comprehensive and early mechanistic understanding of potential off-target liabilities for key preclinical candidates to advance drug development programs.
All recommended selected targets (customization possible upon request) are assembled into a cost-effective panel that provides both robustness and strategic selection of information-rich targets for the evaluation/mitigation of CNS-related off-target effects.
The SafetyScreen CNS panel (item ID: P411) is an ideal complement to the SafetyScreen44 panel (item ID: P270) and the Drug Abuse Potential panel (item ID: P293).
No. of Assays on Panel:
98
Assays on Panel:
Family
GPCR
Name
NK1 Human Tachykinin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
100
Protein
NK1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2C Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1003
Protein
5-HT2C
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
Y1 Human Neuropeptide Y GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
106
Protein
Y1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
Y2 Human Neuropeptide Y GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
107
Protein
Y2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
114
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
118
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (Non-Selective) Rat Ion Channel [3H] TCP Binding LeadHunter Assay - FR
Item
124
Protein
NMDA(PCP site)
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
13
Protein
alpha2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
131
Protein
5-HT1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
H3 Human Histamine GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1332
Protein
H3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2B Human Serotonin GPCR [125I](±)DOI Binding Agonist Radioligand LeadHunter Assay - FR
Item
1333
Protein
5-HT2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2B Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
1344
Protein
alpha2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D2L Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
1405
Protein
D2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT7 Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
144
Protein
5-HT7
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
MT1 Human Melatonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1538
Protein
MT1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
V1A Human Vasopressin / Oxytocin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
159
Protein
V1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2C Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
16
Protein
alpha2C
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav1.2 (L-type) Rat Calcium Ion Channel Binding (Verapamil Site) LeadHunter Assay - FR
Item
163
Protein
CaV1.2 (Vera. site)
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
alpha1B Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
1633
Protein
alpha1B
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav2.2 (N-type) Rat Calcium Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
164
Protein
Cav2.2 (N-type)
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
SKCa (Non-Selective) Rat Potassium Ion Channel [125I] Apamin Binding LeadHunter Assay - FR
Item
167
Protein
SKCa
Organism
Rat
Assay Sub Type
Binding
Family
Protease
Name
Cathepsin B Human Papain Cysteine Peptidase Enzymatic LeadHunter Assay - FR
Item
178
Protein
Cathepsin B
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
18
Protein
beta1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
OX1 Human Orexin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1987
Protein
OX1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
OX2 Human Orexin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
1988
Protein
OX2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
A1 Human Adenosine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
2
Protein
A1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
beta2 Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
20
Protein
beta2
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
ATPase (Na+/K+) Pig Brain Enzymatic LeadHunter Assay - FR
Item
2009
Protein
Na/K ATPase
Organism
Pig
Assay Sub Type
Enzymatic
Family
Neurotransmitter Metabolism
Name
Tyrosine Hydroxylase Rat Enzymatic LeadHunter Assay - FR
Item
214
Protein
Tyrosine Hydroxylase
Organism
Rat
Assay Sub Type
Enzymatic
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
2338
Protein
alpha1A
Organism
Human
Assay Sub Type
Binding
Family
Cytosolic (Other)
Name
Carbonic Anhydrase 2 Human Enzymatic LeadHunter Assay - FR
Item
2572
Protein
Carbonic Anhydrase 2
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
nAChR (alpha7) Human Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
3010
Protein
nAChR
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (alpha4/beta2) Human Ion Channel Binding Agonist Radioligand LeadHunter Assay - FR
Item
3029
Protein
nAChR
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel [3H] Muscimol Binding Agonist Radioligand LeadHunter Assay - FR
Item
3051
Protein
GABAA
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
B2 Human Bradykinin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
33
Protein
B2
Organism
Human
Assay Sub Type
Binding
Family
Protease
Name
ACE Human Angiotensin-Converting Metallo Peptidase Enzymatic LeadHunter Assay - FR
Item
3441
Protein
ACE
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
Monoamine Oxidase B (MAO-B) Human Enzymatic LeadHunter Assay - FR
Item
3477
Protein
MAO-B
Organism
Human
Assay Sub Type
Enzymatic
Family
Transmembrane (Other)
Name
sigma (Non-Selective) Human Binding Agonist Radioligand LeadHunter Assay - FR
Item
3500
Protein
Sigma1/Sigma2
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
NET Human Norepinephrine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
355
Protein
NET
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
Acetylcholinesterase Human Enzymatic LeadHunter Assay - FR
Item
363
Protein
AChE
Organism
Human
Assay Sub Type
Enzymatic
Family
Mitochondrial Function
Name
PBR Human Binding Antagonist Radioligand LeadHunter Assay - FR
Item
3643
Protein
PBR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
37
Protein
CB2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CGRP (CLR/RAMP1) Human Calcitonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
373
Protein
CLR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
mGlu5 Human Glutamate (Metabotropic) GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
3844
Protein
mGlu5
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
OT Human Vasopressin / Oxytocin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
3846
Protein
OT
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCK1 (CCKA) Human Cholecystokinin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
39
Protein
CCK1 (CCKA)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
A2A Human Adenosine GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4
Protein
A2A
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
PDE4D2 Human Phosphodiesterase Enzymatic LeadHunter Assay - FR
Item
4077
Protein
PDE4D
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
CCK2 (CCKB) Human Cholecystokinin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
41
Protein
CCK2 (CCKB)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
5-HT3 Human Serotonin Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
411
Protein
5-HT3A
Organism
Human
Assay Sub Type
Binding
Family
CYP450
Name
CYP1A2 Human CYP450 Enzymatic LeadHunter Assay - FR
Item
4157
Protein
CYP1A2
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
CYP2C19 Human CYP450 Enzymatic LeadHunter Assay - FR
Item
4162
Protein
CYP2C19
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
CYP2D6 Human CYP450 Enzymatic LeadHunter Assay - FR
Item
4163
Protein
CYP2D6
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
CYP3A Human CYP450 (Midazolam substrate) Enzymatic LeadHunter Assay – FR
Item
4166
Protein
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
4376
Protein
5-HT1B
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
SERT Human Serotonin Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
439
Protein
SERT
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D1 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
44
Protein
D1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4461
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel [3H] Flunitrazepam Binding Agonist Radioligand LeadHunter Assay - FR
Item
4518
Protein
GABAA(BZD site)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav1.2 (L-type) Human Calcium Ion Channel Binding (diltiazem site) (benzothiazepines) LeadHunter Assay - FR
Item
4549
Protein
Cav1.2 (L-type)
Organism
Human
Assay Sub Type
Binding
Family
Neurotransmitter Metabolism
Name
Catechol-O-Methyltransferase Pig Enzymatic LeadHunter Assay - FR
Item
457
Protein
Catechol-O-Methyltransferase
Organism
Pig
Assay Sub Type
Enzymatic
Family
Neurotransmitter Metabolism
Name
GABA Transaminase Rat Enzymatic LeadHunter Assay - FR
Item
461
Protein
GABA Transaminase
Organism
Rat
Assay Sub Type
Enzymatic
Family
NHR
Name
GR Human Glucocorticoid NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
469
Protein
GR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
GABAB (B1b/B2) Human GABAB GPCR Mass Spectrometry Binding Antagonist ligand LeadHunter Assay - FR
Item
4699
Protein
GABAB (B1/B2)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4708
Protein
CB1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
471
Protein
5-HT2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D3 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
48
Protein
D3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D4.4 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
49
Protein
D4
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
A2B Human Adenosine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
5
Protein
A2B
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT4E Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
501
Protein
5-HT4
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (Non-Selective) Rat Ion Channel Glycine (Strychnine-Insensitive) Mass Spectrometry Binding LeadHunter Assay - FR
Item
5043
Protein
NMDA(strychine-insensitive site)
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Glycine (Non-Selective) Rat Ion Channel Strychnine Mass Spectrometry Binding LeadHunter Assay - FR
Item
5044
Protein
alpha-1 GlyR
Organism
Rat
Assay Sub Type
Binding
Family
Enzyme
Name
Monoamine Oxidase A (MAO-A) Human Enzymatic LeadHunter Assay - FR
Item
5108
Protein
MAO-A
Organism
Human
Assay Sub Type
Enzymatic
Family
Transporter
Name
Adenosine Guinea Pig Transporter Mass Spectrometry Binding Antagonist Ligand LeadHunter Assay - FR
Item
5113
Protein
SLC29A1
Organism
Guinea Pig
Assay Sub Type
Binding
Family
Transporter
Name
DAT Human Dopamine Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
52
Protein
DAT
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GluK2 Human Ion Channel [3H] Kainic acid Binding LeadHunter Assay - FR
Item
5379
Protein
Kainate
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
ETA Human Endothelin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
54
Protein
ETA
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
ERalpha Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
5484
Protein
ERalpha
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav1.2 (L-type) Human Calcium Ion Channel Binding (Dihydropyridine Site) LeadHunter Assay - FR
Item
5538
Protein
CaV1.2 (DHP site)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Sodium Channel Site2 (Non-selective) Rat Ion Channel Batrachotoxin Mass Spectrometry Binding LeadHunter Assay - FR
Item
5572
Protein
Nav1.5
Organism
Rat
Assay Sub Type
Binding
Family
Kinase
Name
p38alpha (SAPK2A) Human CMGC Kinase Enzymatic Radiometric [Km ATP] LeadHunter Assay - FR
Item
5609
Protein
p38alpha (SAPK2A)
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
JNK1 (alpha1) Human CMGC Kinase Enzymatic Radiometric [Km ATP] LeadHunter Assay - FR
Item
5612
Protein
JNK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
IR (INSR) Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5623
Protein
IR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
EGFR Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5631
Protein
EGFR
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
GABAA (alpha1/beta2/gamma2) Human Ion Channel Picrotoxinin Mass Spectrometry Binding Antagonist Ligand LeadHunter Assay - FR
Item
5666
Protein
GABAA
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
GAT1 Human GABA Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
5773
Protein
GAT-1
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (NMDA, NR1/NR2A) Human Ion Channel [3H] CGP-39653 Binding LeadHunter Assay - FR
Item
5875
Protein
GluN1 / GluN2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
A3 Human Adenosine GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
6
Protein
A3
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (AMPA, Non-Selective) Rat Ion Channel [3H] AMPA Binding LeadHunter Assay - FR
Item
64
Protein
AMPA
Organism
Rat
Assay Sub Type
Binding
Family
Cell Surface (Other)
Name
TNF-alpha Human Binding Agonist Radioligand LeadHunter Assay - FR
Item
76
Protein
TNF-alpha
Organism
Human
Assay Sub Type
Binding
Family
Protease
Name
Cathepsin L Human Papain Cysteine Peptidase Enzymatic LeadHunter Assay - FR
Item
802
Protein
Cathepsin L
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
H1 Human Histamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
870
Protein
H1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
91
Protein
M1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
93
Protein
M2
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
AR Human Androgen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
933
Protein
AR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M3 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
95
Protein
M3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M4 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
96
Protein
M4
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M5 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
97
Protein
M5
Organism
Human
Assay Sub Type
Binding
Testing Information
Test Sample Requirements:
Minimum for Screen: 190 μl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing.
(PBS or HBSS working solutions are not compatible)
Turnaround Time
Standard:
15 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
France - Celle L'Evescault
Questions? Contact Us
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