OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Why choose SafetyScreen59:
The SafetyScreen59 binding provides secondary pharmacology profiling across 59 recommended targets and complete the SafetyScreen18. It includes 33 emerging targets, with strong representation of GPCRs and kinases, enabling early de-risking and broader detection of potential safety liabilities.
It provides follow-up screening after the initial SafetyScreen18 Panel, in order to reach the 77-target safety coverage considered current industry best practices for early off-target risk assessment, as reflected in meta-analysis of Top 20 pharma worldwide under the IQ DruSafe consortium (Brennan et al., Nat Rev Drug Discov , 2024).
The resulting data support safety-margin calculations and earlier risk detection to help advance safer drug candidates.
Key Benefits of SafetyScreen59 binding:
The combination of SafetyScreen18 and SafetyScreen59 is ICH S7A/B aligned for IND-submission.
Fast start & TAT: profiling begins the day after compound receipt. No scheduling, to meet tight deadline and ensure fast TAT of 10 Business Days.
Visualize and interpret your data with In Vitro Safety Insight : identify organ risks, rank compounds, and access follow-up assay recommendations (available in your online account).
Access data early: results released as they are validated.
Final report delivered electronically with notification.
Cost-effective package.
What’s Next:
Follow-up your hit profile in Binding IC₅₀/EC₅₀ or in Functional IC₅₀/EC₅₀ .
No. of Assays on Panel:
58
Assays on Panel:
Family
GPCR
Name
NK3 Human Tachykinin GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
104
Protein
NK3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
114
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
H2 Human Histamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
1208
Protein
H2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
13
Protein
alpha2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
131
Protein
5-HT1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D2L Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
1405
Protein
D2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT6 Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
142
Protein
5-HT6
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
V1A Human Vasopressin / Oxytocin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
159
Protein
V1A
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
KV (Non-Selective) Rat Potassium Ion Channel [125I] alpha-Dendrotoxin Binding LeadHunter Assay - FR
Item
166
Protein
Kv1.1
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
beta1 Human Adrenoceptor GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
18
Protein
beta1
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
RARalpha Human Retinoic Acid NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
2084
Protein
RARalpha
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
PR Human Progesterone NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
2341
Protein
PR
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
Monoamine Oxidase B (MAO-B) Human Enzymatic LeadHunter Assay - FR
Item
3477
Protein
MAO-B
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
37
Protein
CB2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCK1 (CCKA) Human Cholecystokinin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
39
Protein
CCK1 (CCKA)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
A2A Human Adenosine GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4
Protein
A2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCK2 (CCKB) Human Cholecystokinin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
41
Protein
CCK2 (CCKB)
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
5-HT3 Human Serotonin Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
411
Protein
5-HT3A
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
COX1 Human Cyclooxygenase Enzymatic LeadHunter Assay - FR
Item
4173
Protein
COX1
Organism
Human
Assay Sub Type
Enzymatic
Family
Enzyme
Name
COX2 Human Cyclooxygenase Enzymatic LeadHunter Assay - FR
Item
4186
Protein
COX2
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
MRGX2 (MRGPRX2) Human Class A Orphan GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - FR
Item
4282
Protein
MRGX2 (MRGPRX2)
Organism
Human
Assay Sub Type
Cell Based
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
4376
Protein
5-HT1B
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
SERT Human Serotonin Transporter Binding Antagonist Radioligand LeadHunter Assay - FR
Item
439
Protein
SERT
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
4461
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
GR Human Glucocorticoid NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
469
Protein
GR
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT2A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
471
Protein
5-HT2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
D3 Human Dopamine GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
48
Protein
D3
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
Monoamine Oxidase A (MAO-A) Human Enzymatic LeadHunter Assay - FR
Item
5108
Protein
MAO-A
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
ETA Human Endothelin GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
54
Protein
ETA
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
ERalpha Human Estrogen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
5484
Protein
ERalpha
Organism
Human
Assay Sub Type
Binding
Family
Kinase
Name
GSK3beta (GSK3B) Human CMGC Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5610
Protein
GSK3beta
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Src Human TK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5611
Protein
Src
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ROCK2 Human AGC Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5620
Protein
ROCK2
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
IR (INSR) Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5623
Protein
IR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Aurora-A (AURKA) Human Other Protein Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5628
Protein
Aurora-A
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
EGFR Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5631
Protein
EGFR
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
c-Kit Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5633
Protein
Kit
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
TRKA Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5634
Protein
TRKA
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
FGFR1 Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5635
Protein
FGFR1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ROCK1 Human AGC Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5637
Protein
ROCK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
KDR (VEGFR2) (KDR) Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5639
Protein
KDR (VEGFR2)
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Flt-1 (VEGFR1) (FLT1) Human RTK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5641
Protein
Flt-1 (VEGFR1)
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
GPBA (TGR5) Human Bile acid GPCR Binding Agonist Radioligand LeadHunter Assay - FR
Item
5713
Protein
GPBA receptor
Organism
Human
Assay Sub Type
Binding
Family
Epigenetic
Name
BRD4 (1) Human Bromodomain-Containing 4 Binding LeadHunter Assay - FR
Item
5716
Protein
BRD4
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
MALT1 Human Protease Enzymatic Fluorimetry LeadHunter Assay - FR
Item
5717
Protein
MALT1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
PDHK1 (PDK1) Human Kinase Other protein Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5810
Protein
PDK1
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
Aurora-B (AURKB) Human Other Protein Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5811
Protein
Aurora-B
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
FAK Human TK Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5813
Protein
FAK
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
MKK7 (MAP2K7) Human Kinase STE Enzymatic [Km ATP] SafetyScreen - FR
Item
5814
Protein
MAPKK 7
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
ATM Human PIKK Kinase Enzymatic [Km ATP] SafetyScreen - FR
Item
5815
Protein
ATM
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
PI3Kgamma (PIK3CG) (p120gamma) Human PtdIns(4,5)P 3-Kinase Enzymatic [Km ATP] SafetyScreen - FR
Item
5816
Protein
PI3Kgamma
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
CLIK (STK35) Human Other Protein Kinase Enzymatic Radiometric [Km ATP] SafetyScreen - FR
Item
5817
Protein
CLIK
Organism
Human
Assay Sub Type
Enzymatic
Family
Ion Channel
Name
Glutamate (NMDA, NR1/NR2A) Human Ion Channel [3H] CGP-39653 Binding LeadHunter Assay - FR
Item
5875
Protein
GluN1 / GluN2A
Organism
Human
Assay Sub Type
Binding
Family
Enzyme
Name
Cathepsin D Human Pepsin Aspartic Peptidase Enzymatic LeadHunter Assay - FR
Item
650
Protein
Cathepsin D
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
M1 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
91
Protein
M1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
M2 Human Acetylcholine (Muscarinic) GPCR Binding Antagonist Radioligand LeadHunter Assay - FR
Item
93
Protein
M2
Organism
Human
Assay Sub Type
Binding
Family
NHR
Name
AR Human Androgen NHR Binding Agonist Radioligand LeadHunter Assay - FR
Item
933
Protein
AR
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (Alpha1, Muscle-Type) Human Ion Channel Binding Antagonist Radioligand LeadHunter Assay - FR
Item
936
Protein
nAChR-α1
Organism
Human
Assay Sub Type
Binding
Testing Information
Test Sample Requirements:
Minimum for Screen: 160 μl of 10 mM stock -OR- 1 mg (pre-weighed) for 10 µM final testing.
(PBS or HBSS working solutions are not compatible)
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
SafetyScreen
Testing Location:
France - Celle L'Evescault
RELATED SOLUTIONS
SafetyScreen18 Core Panel - FR
Item: P447
SafetyScreen77 Core Extended Panel - FR
Item: P456
SafetyScreen59 Functional Extended Panel - FR
Item: P458-EU
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