OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Pain is a very common distressing disease. The development of medical therapeutic treatment for pain is essential. GPCRs, ion channels, neurotransmitters, transporters and enzymes have been implicated in the pathophysiology of all types of pain. To identify molecular target compound for pain, we address molecular targets relevant to pain perception to provide the discovery and research of screening analgesics on pain treatment.
No. of Assays on Panel:
43
Assays on Panel:
Family
Lipid Metabolism
Name
COX1 Human Cyclooxygenase Enzymatic LeadHunter Assay - TW
Item
116030
Protein
COX1
Organism
Human
Assay Sub Type
Enzymatic
Family
Lipid Metabolism
Name
COX2 Human Cyclooxygenase Enzymatic LeadHunter Assay - TW
Item
118030
Protein
COX2
Organism
Human
Assay Sub Type
Enzymatic
Family
Nitrogen Metabolism
Name
nNOS Rat Nitric Oxide Synthase Enzymatic LeadHunter Assay - TW
Item
142000
Protein
nNOS
Organism
Rat
Assay Sub Type
Enzymatic
Family
Kinase
Name
TRKA Human RTK Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW
Item
175040
Protein
TRKA
Organism
Human
Assay Sub Type
Enzymatic
Family
Kinase
Name
SAPK2A (p38alpha) Human CMGC Kinase Enzymatic Radiometric LeadHunter Assay [10 μM ATP] - TW
Item
176610
Protein
p38alpha (SAPK2A)
Organism
Human
Assay Sub Type
Enzymatic
Family
Lipid Metabolism
Name
Fatty Acid Amide Hydrolase Human Enzymatic LeadHunter Assay - TW
Item
199008
Protein
Fatty Acid Amide Hydrolase
Organism
Human
Assay Sub Type
Enzymatic
Family
GPCR
Name
A3 Human Adenosine GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
200720
Protein
A3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha1A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
203110
Protein
alpha1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2A Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
203630
Protein
alpha2A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
alpha2C Human Adrenoceptor GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
203810
Protein
alpha2C
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
NET Human Norepinephrine Transporter Binding Antagonist Radioligand LeadHunter Assay - TW
Item
204410
Protein
NET
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
AT2 Human Angiotensin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
210120
Protein
AT2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
B1 Human Bradykinin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
212520
Protein
B1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
B2 Human Bradykinin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
212620
Protein
B2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CGRP (CLR/RAMP1) Human Calcitonin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
214020
Protein
CLR
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Cav2.2 (N-type) Human Calcium Ion Channel [3H] Gabapentin Binding Antagonist Radioligand LeadHunter Assay - TW
Item
216020
Protein
Cav2.2 (N-type)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB1 Human Cannabinoid GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
217050
Protein
CB1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CB2 Human Cannabinoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
217100
Protein
CB2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
CCR2 Human Chemokine GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
217550
Protein
CCR2
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (Non-Selective) Rat Ion Channel [3H] Flunitrazepam Binding Agonist Radioligand LeadHunter Assay - TW
Item
226600
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (NMDA, NR1/NR2A) Human Ion Channel [3H] CGP-39653 Binding LeadHunter Assay - TW
Item
232820
Protein
GluN1/ GluN2A
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (NMDA, Non-Selective) Rat Ion Channel [3H] MDL 105,519 Binding LeadHunter Assay - TW
Item
232910
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
Glutamate (Non-Selective) Rat Ion Channel [3H] TCP Binding LeadHunter Assay - TW
Item
233000
Protein
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
H3 Human Histamine GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
239820
Protein
H3
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
NK1 Human Tachykinin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
255520
Protein
NK1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
NT1 Human Neurotensin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
258010
Protein
NT1
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (alpha3/beta4) Human Ion Channel Binding Agonist Radioligand LeadHunter Assay - TW
Item
258730
Protein
nAChR-a3b4
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
delta (DOP) Human Opioid GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
260130
Protein
delta (DOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
kappa (KOP) Human Opioid GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
260210
Protein
kappa (KOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
mu (MOP) Human Opioid GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
260410
Protein
mu (MOP)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
EP1 Human Prostanoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
268110
Protein
EP1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
EP2 Human Prostanoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
268200
Protein
EP2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
EP4 Human Prostanoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
268420
Protein
EP4
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT1A Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
271110
Protein
5-HT1A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT1B Human Serotonin GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
271230
Protein
5-HT1B
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
5-HT3 Human Serotonin Ion Channel Binding Antagonist Radioligand LeadHunter Assay - TW
Item
271910
Protein
5-HT3A
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
5-HT7 Human Serotonin GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
272320
Protein
5-HT7
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
SERT Human Serotonin Transporter Binding Antagonist Radioligand LeadHunter Assay - TW
Item
274030
Protein
SERT
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Nav1.5 Sodium Channel Human Ion Channel [3H]BNZA Binding LeadHunter Assay - TW
Item
279520
Protein
Nav1.5
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
EP3 Human Prostanoid GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
299006
Protein
EP3
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
nAChR (alpha7) Human Ion Channel Binding Antagonist Radioligand LeadHunter Assay - TW
Item
299032
Protein
nAChR
Organism
Human
Assay Sub Type
Binding
Family
Transmembrane (Other)
Name
sigma1 Human Binding Agonist Radioligand LeadHunter Assay - TW
Item
299034
Protein
sigma1
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
P2X (Non-Selective) Rat Ion Channel Binding Agonist Radioligand LeadHunter Assay - TW
Item
299036
Protein
Organism
Rat
Assay Sub Type
Binding
Assay Information
Assay Type:
Biochemical
Testing Information
Test Concentration / Dose:
Suggested concentration for initial testing is 10 µM
Test Sample Requirements:
120 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
LeadHunter
Testing Location:
Taiwan - Taipei
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