OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
We address most ion channel targets that may cause membrane depolarization while getting blocked by test compounds. One transporter and well-known GPCRs highly related to seizure are also selected. The compounds against selecting targets depolarize cell membrane and recruit more excitability to neural circuit, further causing seizure occurrence. This seizure liability panel is to prioritize profiling test compounds against targets relevant to seizure safety concerns for potential risk in drug discovery, to get better drug candidates and reduce the attrition rate.
No. of Assays on Panel:
15
Assays on Panel:
Family
GPCR
Name
A1 Human Adenosine GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
200510
Protein
A1
Organism
Human
Assay Sub Type
Binding
Family
Transporter
Name
GABA (Non-Selective) Rat Transporter Binding Antagonist Radioligand LeadHunter Assay - TW
Item
226400
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (Non-Selective) Rat Ion Channel [3H] Muscimol Binding Agonist Radioligand LeadHunter Assay - TW
Item
226500
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (Non-Selective) Rat Ion Channel [3H] Flunitrazepam Binding Agonist Radioligand LeadHunter Assay - TW
Item
226600
Protein
Organism
Rat
Assay Sub Type
Binding
Family
Ion Channel
Name
GABAA (Non-Selective) Rat Ion Channel [3H] TBOB Binding Antagonist Radioligand LeadHunter Assay - TW
Item
226810
Protein
Organism
Rat
Assay Sub Type
Binding
Family
GPCR
Name
GABAB (B1a/B2) Human GABAB GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
228610
Protein
GABAB (B1/B2)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
GABAB (B1b/B2) Human GABAB GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
228710
Protein
GABAB (B1/B2)
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
mGlu2 Human Glutamate (Metabotropic) GPCR Binding Antagonist Radioligand LeadHunter Assay - TW
Item
236400
Protein
mGlu2
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
mGlu5 Human Glutamate (Metabotropic) GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
237000
Protein
mGlu5
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
Glycine alpha1 Human Ion Channel [3H] Strychnine Binding LeadHunter Assay - TW
Item
239010
Protein
GLRA1
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
Y1 Human Neuropeptide Y GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
257010
Protein
NPY1R
Organism
Human
Assay Sub Type
Binding
Family
GPCR
Name
Y2 Human Neuropeptide Y GPCR Binding Agonist Radioligand LeadHunter Assay - TW
Item
257110
Protein
Y2
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
KATP Hamster Potassium Ion Channel Binding Antagonist Radioligand LeadHunter Assay - TW
Item
265600
Protein
KATP
Organism
Hamster
Assay Sub Type
Binding
Family
Ion Channel
Name
Kv1.1 Human Potassium Channel Binding Antagonist Radioligand LeadHunter Assay – TW
Item
265710
Protein
Kv1.1
Organism
Human
Assay Sub Type
Binding
Family
Ion Channel
Name
SKCa (Non-Selective) Rat Potassium Ion Channel [125I] Apamin Binding LeadHunter Assay - TW
Item
265800
Protein
Organism
Rat
Assay Sub Type
Binding
Assay Information
Assay Type:
Biochemical
Testing Information
Test Concentration / Dose:
Suggested concentration for initial testing is 10 µM
Test Sample Requirements:
100 μl of a 10 mM stock or 1 mg pre-weighed powder (assuming FW≦500 and purity 100%)
Turnaround Time
Standard:
10 Business Days
Clinical Relevance
Therapeutic Area:
CNS/Addiction/Pain
Additional Information
Brand:
SafetyScreen
Testing Location:
Taiwan - Taipei
Questions? Contact Us
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