A1 Human Adenosine GPCR Cell Based Agonist cAMP LeadHunter Assay - US

Background Information:

Adenosine receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Adenosine receptors may also be called P1 receptors, which are distinguished from transmitter-gated ion channels (P2X receptors) and G protein-coupled receptors (P2Y).

cAMP Hunter™ Gi cell lines overexpress naturally Gi coupled, wild type GPCRs and are designed to detect inhibition of intracellular cAMP production in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Adenosine

Class:

Class A

Coupling:

Gi/Go

Protein Name:

A1

Uniprot Number:

P30542

Gene Name:

ADORA1

Gene ID:

134

Gene Aliases:

RDC7

Accession Number:

AY136746

Organism:

Human

Cell Type:

CHO-K1