alpha2C Human Adrenoceptor GPCR Cell Based Agonist cAMP LeadHunter Assay - US

Background Information:

Adrenoreceptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Adrenoreceptors are found in most peripheral tissue and within the central nervous system. Adrenergic a2C receptor may cause peripheral vasoconstriction; antagonism may act peripherally to increase the skeletal muscle blood flow.

cAMP Hunter™ Gi cell lines overexpress naturally Gi coupled, wild type GPCRs and are designed to detect inhibition of intracellular cAMP production in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Adrenoceptor

Class:

Class A

Coupling:

Gi/Go

Protein Name:

alpha2C

Uniprot Number:

P18825

Protein Aliases:

Alpha-2C adrenoreceptor|Alpha-2C adrenoceptor|Alpha-2CAR

Gene Name:

ADRA2C

Gene ID:

152

Gene Aliases:

ADRA2L2|ADRA2RL2

Accession Number:

NM_000683

Organism:

Human

Cell Type:

CHO-K1