APJ Human Apelin GPCR Cell Based Antagonist cAMP LeadHunter Assay - US

Background Information:

APJ (apelin) belongs to the superfamily of seven transmembrane G-protein-coupled receptors, which constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. APJ receptors are found in the lung, heart, and hypothalamic region.

cAMP Hunter™ Gi cell lines overexpress naturally Gi coupled, wild type GPCRs and are designed to detect inhibition of intracellular cAMP production in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Apelin

Class:

Class A

Coupling:

Gi/Go

Protein Name:

APJ

Uniprot Number:

P35414

Protein Aliases:

APJ (apelin) receptor

Gene Name:

APLNR

Gene ID:

187

Gene Aliases:

FLJ90771|APJ|APJR

Accession Number:

NM_005161

Organism:

Human

Cell Type:

CHO-K1