APJ Mouse Apelin GPCR Cell Based Agonist cAMP (TR-FRET in Arrestin Cell Line) LeadHunter Assay - US

Background Information:

APJ (apelin) belongs to the superfamily of seven transmembrane G-protein-coupled receptors, which constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. APJ receptors are found in the lung, heart, and hypothalamic region.
PathHunter β-Arrestin GPCR cell lines measure intracellular cAMP using TR-FRET technology. The PathHunter cell line used in this assay are engineered to co-express the ProLink™ (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin.

Family:

GPCR

Sub Family:

Apelin

Class:

Class A

Coupling:

Gi/Go

Protein Name:

APJ

Uniprot Number:

Q9WV08

Protein Aliases:

APJ (apelin) receptor

Gene Name:

APLNR

Gene ID:

23796

Gene Aliases:

Agtrl1|Apj

Accession Number:

NM_011784.2

Organism:

Mouse

Cell Type:

CHO-K1