Aurora-A (AURKA) Human Other Protein Kinase KINOMEscan KdELECT Binding LeadHunter Assay - US

Background Information:

Protein serine/threonine kinase Aurora-A (STK6, STK15, BTAK, AIK, ARK1, AURA, Aurora-related kinase 1, Breast-tumor-amplified kinase) is one of a family of serine-threonine kinases that have been strongly linked to chromosome segregation and centrosome functions. There are three isoforms of Aurora kinase: A, B, and C. Molecular mechanism of Aurora-A regulation of G2-M transition is phosphorylation of histone H3. Inhibition of Aurora A may be useful in the treatment of many types of human cancer, including leukemia, colon and breast cancer.

Family:

Kinase

Sub Family:

Other Protein Kinase

Class:

Protein Ser/Thr

Protein Name:

Aurora-A

Uniprot Number:

O14965

Protein Aliases:

protein phosphatase 1, regulatory subunit 47|Aurora-A kinase

Gene Name:

AURKA

Gene ID:

6790

Gene Aliases:

BTAK|AurA|STK7|ARK1|PPP1R47|AIK

Accession Number:

NP_003591.2

Organism:

Human

Construct Details:

Wild Type; Partial Length (Start/Stop: E122/K401); Mammalian Expression