beta Glucuronidase Bovine Enzymatic LeadHunter Assay - TW

Background Information:

b-Glucuronidase is involved in the degradation of heparin/heparan sulfate and dermatan/chondroitin sulfate. In vivo, deficiency of the enzyme is associated with the lysosomal storage disorder muco-polysaccharidosis type VII (MPS VII), or Sly syndrome, due to accumulation of partially degraded heparin/heparan sulfate and dermatan sulfate fragments. By uncoupling glucuronides, b-glucuronidase can deconjugate potential toxins, increasing the formation of carcinogens in the bowel and promoting the enterohepatic recirculation of toxins, hormones, and various drugs in the body. In fact, excessive b-glucuronidase may be a primary factor in the etiology of colon cancer.

Family:

Carbohydrate Metabolism

Sub Family:

Glycoside Hydrolase

Protein Name:

Beta Glucuronidase

Uniprot Number:

P08236

Gene Name:

GUSB

Gene ID:

2990

Organism:

Bovine

Construct Details:

Endogenous