beta3 Human Adrenoceptor GPCR Cell Based Antagonist cAMP LeadHunter Assay - US

Background Information:

There are three known subtypes of b-adrenergic receptors, b1, b2, and b3, all of which are thought to couple primarily via Gsa to adenylyl cylase, leading to an increase in cAMP. The receptor subtypes differ primarily in their location: b1-adrenoceptors predominate in the heart, cerebral cortex, and the kidney. The major subtype in the lungs, cerebellum, uterus, skeletal muscle, and blood vessels is the b2-adrenoceptor. The b3-adrenoceptor has been detected in brain, stomach, and gall bladder but are expressed predominantly in white and brown adipose tissue (WAT and BAT, respectively) and selective agonists may be potentially useful as anti-obesity drugs.

cAMP Hunter™ Gs cell lines overexpress naturally Gs coupled, wild type GPCRs and are designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Adrenoceptor

Class:

Class A

Coupling:

Gs

Protein Name:

beta3

Uniprot Number:

P13945

Protein Aliases:

Beta-3 adrenoceptor

Gene Name:

ADRB3

Gene ID:

155

Accession Number:

NM_000025

Organism:

Human

Cell Type:

DLD1