OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
This panel of assays is intended to assess whether a test compound is a substrate of the P-glycoprotein and/or BCRP efflux transporters expressed in Caco-2 cells. The permeability of the test compound in this cell line is determined in the AB and BA directions with and without the addition of a Pgp-specific inhibitor (verapamil) or a BCRP specific inhibitor Ko143.
No. of Assays on Panel:
6
Assays on Panel:
Family
Name
A-B permeability (Caco-2, pH 7.4/7.4) - US
Item
3319
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Name
B-A permeability (Caco-2, pH 7.4/7.4) - US
Item
3321
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Name
A-B permeability (Caco-2, pH 7.4/7.4 + verapamil) - US
Item
3325
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Name
B-A permeability (Caco-2, pH 7.4/7.4 + verapamil) - US
Item
3326
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Name
A-B permeability (Caco-2 pH 7.4/7.4 + Ko143) - US
Item
4482
Protein
Organism
Human
Assay Sub Type
Cell Based
Family
Name
B-A permeability (Caco-2 pH 7.4/7.4 + Ko143) - US
Item
4483
Protein
Organism
Human
Assay Sub Type
Cell Based
Family:
Transporter
Sub Family:
ABCB
Class:
ABC
Organism:
Human
Construct Details:
Endogenous
Cell Type:
Caco-2
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Testing Information
Test Sample Requirements:
Minimum for 1) Screen: 100 μl of 10 mM stock -OR- 1 to 2 mg (pre-weighed). 2) Dose Response: 250 μl of 10 mM stock -OR- 1.5 to 2 mg (pre-weighed).
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
Cerep
Testing Location:
USA - St Charles, MO
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