CB2 Human Cannabinoid GPCR Cell Based Agonist cAMP LeadHunter Assay - US

Background Information:

Cannabinoid receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Cannabinoid CB2 receptors are found primarily in immune tissues. .

cAMP Hunter™ Gi cell lines overexpress naturally Gi coupled, wild type GPCRs and are designed to detect inhibition of intracellular cAMP production in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Cannabinoid

Class:

Class A

Coupling:

Gi/Go

Protein Name:

CB2

Uniprot Number:

P34972

Protein Aliases:

CB2|hCB2|CX5

Gene Name:

CNR2

Gene ID:

1269

Gene Aliases:

CB2

Accession Number:

AY242132

Organism:

Human

Cell Type:

CHO-K1