OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Drug-induced liver injury (DILI) is one of the leading causes of drug attrition during development and post-marketing drug withdrawal. Mice are commonly used in in vivo toxicology and pharmacokinetic (PK) studies. Primary mouse hepatocytes are considered a relevant in vitro model for evaluating drug-induced hepatotoxicity because, under appropriate culture conditions, they retain many hepatocyte-specific functions, including the expression and activity of Phase I and Phase II drug-metabolizing enzymes and drug transporters.Eurofins performs hepatocyte cell viability assays using cryopreserved, plateable primary mouse hepatocytes. Cell viability is assessed using the CellTiter-Glo® assay (Promega) or other appropriate viability reagents, depending on study requirements.
Organism:
Mouse
Construct Details:
Endogenous
Cell Type:
Hepatocytes
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Testing Information
Test Sample Requirements:
Minimum for 1) Screen: 50 µl of 20 mM stock -OR- 1 to 2 mg (pre-weighed). 2) Dose Response: 100 µl of 20 mM stock -OR- 1 to 2 mg (pre-weighed)
Minimum Order Quantity:
8
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
Cerep
Testing Location:
USA - St Charles, MO
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