OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Run using the FDA preferred CiPA Protocol, the hERG potassium channel is a major molecular component of the delayed rectifier current (IKr) underlying cardiac repolarization. Due to either genetic defects in its pore-forming subunit or adverse drug effects, decreased hERG activity prolongs the QT interval and can lead to the potentially lethal ventricular arrhythmia Torsades de pointes. The implication of (IKr) in cardiac arrhythmias and in anti-arrhythmic/pro-arrhythmic actions of drugs has driven intensive research interests in its structure-function relationship, the linkage between LQT-associated mutations and changes in channel function, and the mechanism of drug actions.
Family:
Ion Channel
Sub Family:
Potassium
Class:
Voltage-Gated
Organism:
Human
Cell Type:
CHO-K1
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Antagonist
Platform:
Qube®
Testing Information
Test Sample Requirements:
Minimum for 1) Screen: 150 μl of 300X stock based on the top concentration to be tested -OR- 3 mg (pre-weighed). 2) Dose Response: 150 μl of 300X stock based on the top concentration to be tested -OR- 3 mg (pre-weighed).
Minimum Order Quantity:
36
Turnaround Time
Standard:
5 Business Days
Service Scheduling Note:
To accommodate the express TAT, test concentration are fixed at (10uM for single point assay; 30,10,3,1,0.3,0.1uM for DR assay) and cannot be customized.
Additional Information
Brand:
IonChannelProfiler
Testing Location:
USA - St Charles, MO
Other Information:
No pdf report, only data tables as standard deliverables.
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