CT Human Calcitonin GPCR Cell Based Antagonist cAMP LeadHunter Assay - US

Background Information:

Calcitonin receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The calcitonin family of peptides comprises calcitonin, amylin, two calcitonin related peptides (CGRPs) and adrenomedullin. Calcitonin receptor agonism is effective in Paget’s disease and some patients with osteoporosis. Agonism may also result in hypocalcemia and hypophosphatemia by direct inhibition of osteoclastic bone resorption.

cAMP Hunter™ Gs cell lines overexpress naturally Gs coupled, wild type GPCRs and are designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Calcitonin

Class:

Class B

Coupling:

Gs

Protein Name:

CT

Uniprot Number:

P30988

Gene Name:

CALCR

Gene ID:

799

Gene Aliases:

CTR

Accession Number:

NM_001742.2

Organism:

Human

Cell Type:

CHO-K1