OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Drug-induced liver injury (DILI) is one of the major reasons that drugs are withdrawn from market. Human primary hepatocytes (HPH) are currently considered as the gold standard in vitro model system to study drug induced hepatotoxicity. Lactate dehydrogenase (LDH) released into the culture medium upon plasma membrane damage is considered as one of the hallmarks of cytotoxicity. Eurofins performs the cytotoxicity assessment using cryopreserved platable human primary hepatocytes from single donor. LDH-Glo (Promega) is used as a cytotoxicity assessment.
Organism:
Human
Construct Details:
Endogenous
Cell Type:
Hepatocytes
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Testing Information
Test Sample Requirements:
Minimum for 1) Screen: 50 µl of 20 mM stock -OR- 1 to 2 mg (pre-weighed). 2) Dose Response: 100 µl of 20 mM stock -OR- 1 to 2 mg (pre-weighed)
Minimum Order Quantity:
8
Turnaround Time
Standard:
10 Business Days
Additional Information
Brand:
Cerep
Testing Location:
USA - St Charles, MO
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