OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Opiates exert their effects in the central and peripheral nervous systems through interaction with m, k and d, three major types of opioid receptors, which are structural homologues and belong to the G protein-coupled receptor (GPCR) family. G-protein cascades activated by these three receptors can reduce adenylyl cyclase activity, alter inositol trisphosphate turnover, activate G-protein-linked, inward potassium channels, and close calcium channels. These receptors mediate the actions of opiate drugs and endogenous opioid neuropeptides in producing euphoria, modulating pain perception, and altering other important functions in the central and peripheral nervous systems. Opioid analgesics provide symptomatic relief of pain, cough and diarrhea.
Family:
GPCR
Sub Family:
Opioid
Class:
Class A
Protein Name:
delta (DOP)
Uniprot Number:
P41143
Protein Aliases:
DOR-1
Gene Name:
OPRD1
Gene ID:
4985
Gene Aliases:
OPRD
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist
Testing Information
Test Sample Requirements:
300uL of a 1000X stock based on the top or final concentration being tested
Turnaround Time
Standard:
20 Business Days
Service Scheduling Note:
Eurofins DiscoverX will make reasonable efforts to deliver screening data within (20) business days from the start date of the scheduled assay service provided that Materials and required documentation are received prior to run date.
Clinical Relevance
Adverse / Beneficial Action:
Opiate d receptor agonism may be analgesic and reduce gastrointestinal transit
Additional Information
Brand:
SafetyScreen
Testing Location:
USA - San Diego, CA
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