DP1 Human Prostanoid GPCR Cell Based Antagonist cAMP LeadHunter Assay - US

Background Information:

Prostanoid receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The DP1 prostanoid receptor is activated by prostaglandin D2 (PGD2) and it is expressed in vascular smooth muscle, platelets, retina and hematopoietic cells. Activation of DP1 results in inhibition of platelet activation and vasodilation; they are also involved in sleep regulation. Prostanoid DP1 receptors may also play a role in immune and inflammatory responses. The potential therapeutic utilities of DP1 receptor agonists are for glaucoma, atopic dermatitis and antagonist for dyslipidemia and asthma, respectively.

cAMP Hunter™ Gs cell lines overexpress naturally Gs coupled, wild type GPCRs and are designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Prostanoid

Class:

Class A

Coupling:

Gs

Protein Name:

DP1

Uniprot Number:

Q13258

Gene Name:

PTGDR

Gene ID:

5729

Gene Aliases:

DP|DP1|PTGDR1

Accession Number:

NM_000953

Organism:

Human

Cell Type:

CHO-K1