Ectonucleotide Pyrophosphatase/Phosphodiesterase 1 (ENPP1) Human Enzymatic LeadHunter Assay - TW

Background Information:

Ecto-nucleotide pyrophosphatase/phosphodiesterase 1 (ENPP1), a metalloenzyme, is a homodimer type II transmembrane glycoprotein characterized by an N-terminal transmembrane domain, two somatomedin-B-like domains, a catalytic domain, and a C-terminal nuclease-like domain. ENPP1 hydrolyzes a wide range of phosphodiester bonds. The main substrate of ENPP1 is ATP, which is cleaved into AMP and diphosphate. Another notable nucleotide substrate is NAD+ which can be hydrolyzed to produce AMP. The enzyme is involved in bone mineralization, soft-tissue calcification, insulin receptor signaling, cancer cell proliferation, and immune modulation. Diseases associated with ENPP1 include generalized arterial calcification of infancy, ossification of the posterior longitudinal ligament of the spine (OPLL), hypophosphatemic rickets autosomal recessive 2 (ARHR2), and insulin resistance.

Family:

Phosphatase

Class:

Protein (enzyme)

Protein Name:

ENPP1

Uniprot Number:

P22413

Protein Aliases:

Membrane component chromosome 6 surface marker 1

Gene Name:

ENPP1

Gene ID:

5167

Gene Aliases:

PC-1; PCA1

Accession Number:

NM_006208

Organism:

Human

Construct Details:

Fragment, Recombinant