Ectonucleotide Pyrophosphatase/Phosphodiesterase 2 (ENPP2) Human Enzymatic LeadHunter Assay - TW

Background Information:

Ectonucleotide pyrophosphatase/phosphodiesterase family member 2 (ENPP 2), also known as autotaxin, is produced as a pre-proenzyme glycoprotein and activated by the removal of its N-terminal signal peptide resulting in a matured secreted form, consists of 4 domains, two N‐terminal SMB‐like domains, a central catalytic PDE domain, and an inactive nuclease‐like domain. ENPP2 acts as a lysophospholipase D, mainly hydrolyzing extracellular lysophosphatidylcholine (LPC) to lysophosphatidic acid (LPA). LPA, like a growth factor in serum, could induce motility in fibroblasts and cancer cells through GPCRs. Deregulation of the LPA signaling axis has been linked to different diseases, such as liver disease, fibrosis, pruritus, multiple sclerosis, inflammation, and cancer. A specific ENPP2 inhibitor against idiopathic pulmonary fibrosis showed promising results in the clinical trial, and the inhibition of ENPP2 also can stimulate T-cell infiltration into tumors and enhance the efficacy of immunotherapy for liver disease and pancreatic cancer.

Family:

Phosphatase

Class:

Protein (enzyme)

Protein Name:

ENPP2

Uniprot Number:

Q13822

Protein Aliases:

Autotaxin; Extracellular lysophospholipase D (LysoPLD)

Gene Name:

ENPP2

Gene ID:

5168

Gene Aliases:

ATX; PD-IALPHA

Accession Number:

NM_001040092

Organism:

Human

Construct Details:

Fragment, Recombinant