EP1 Human Prostanoid GPCR Cell Based Agonist Calcium Flux LeadHunter Assay - US

Background Information:

Prostanoid receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. The EP1 prostanoid receptor is activated by prostaglandin E2 (PGE2) and it is most highly expressed in Kidney, myometrium and GI smooth muscle.

DiscoverX® Calcium cell lines overexpress naturally Gq coupled, wildtype GPCRs and are designed to detect calcium mobilization in response to agonist stimulation of the receptor. Signal can be detected using the Calcium No WashPLUS Detection Kit.

Family:

GPCR

Sub Family:

Prostanoid

Class:

Class A

Coupling:

Gq

Protein Name:

EP1

Uniprot Number:

P34995

Protein Aliases:

PGE2 receptor EP1 subtype|Prostanoid EP1 receptor

Gene Name:

PTGER1

Gene ID:

5731

Gene Aliases:

EP1

Accession Number:

NM_000955.2

Organism:

Human

Cell Type:

CHO-K1