FGFR3 (N540K) Human RTK Kinase KINOMEscan ELECT Binding LeadHunter Assay - US

Background Information:

Fibroblast growth factor (FGF) superfamily consists of 23 members, all of which contain a conserved 120 amino acid (aa) core region that contains six identical, interspersed amino acids. Based on the pI factor, two main groups of FGF are named: acidic FGF (aFGF) and basic FGF (bFGF). The superfamily members act extracellularly through four tyrosine kinase FGF receptors (FGR1 through FGR4), with multiple specificities noted for almost all FGFs. Biological binding of aFGF to its receptors will result in phosphorylation of the receptor and non-receptor proteins and generate its function. FGR3 (FGFR-3, Fibroblast growth factor receptor 3, EC 2.7.1.112) is expressed mainly in bone, central nervous system and tumors. Inhibition of FGFR3 may be useful in the treatment of dwarfism as well as some tumors.

Family:

Kinase

Sub Family:

RTK

Class:

Protein Tyrosine

Protein Name:

FGFR3

Uniprot Number:

P22607

Protein Aliases:

CD antigen CD333

Gene Name:

FGFR3

Gene ID:

2261

Gene Aliases:

CEK2|JTK4|CD333

Accession Number:

NP_000133.1

Organism:

Human

Construct Details:

Mutation (N540K); Partial Length (Start/Stop: R442/S771); Bacterial Expression