FPR2 Human Formylpeptide GPCR Cell Based Antagonist cAMP LeadHunter Assay - US

Background Information:

N-formyl peptide receptors (FPR) belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. FPR as well as FPRL1 (FPR-like 1) and FPRL2 are chemoattractant receptors.

cAMP Hunter™ Gi cell lines overexpress naturally Gi coupled, wild type GPCRs and are designed to detect inhibition of intracellular cAMP production in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Formylpeptide

Class:

Class A

Coupling:

Gi/Go

Protein Name:

FPR2

Uniprot Number:

P25090

Protein Aliases:

FMLP-R-I|Formyl peptide receptor-like 1|HM63|Lipoxin A4 receptor|LXA4 receptor|RFP

Gene Name:

FPR2

Gene ID:

2358

Gene Aliases:

LXA4R|HM63|FPRH2|FMLPX|FPR2A|FMLP-R-II|ALXR|FPR|FMLP

Accession Number:

AY225226

Organism:

Human

Cell Type:

CHO-K1