OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
This assay is intended to assess whether a test compound is a substrate of the P-glycoprotein efflux transporter expressed in MDCKII cells. The permeability of the test compound in this cell line is determined in the AB and BA directions with and without the addition of a Pgp-specific inhibitor (verapamil).
No. of Assays on Panel:
4
Assays on Panel:
Family
Transporter
Name
A-B permeability (MDR1-MDCKII, pH 7.4/7.4) - US
Item
1809
Protein
P-gp
Organism
Human
Assay Sub Type
Cell Based
Family
Transporter
Name
B-A permeability (MDR1-MDCKII, pH 7.4/7.4) - US
Item
1810
Protein
P-gp
Organism
Human
Assay Sub Type
Cell Based
Family
Transporter
Name
A-B permeability (MDR1-MDCKII, pH 7.4/7.4 + verapamil) - US
Item
2081
Protein
P-gp
Organism
Human
Assay Sub Type
Cell Based
Family
Transporter
Name
B-A permeability (MDR1-MDCKII, pH 7.4/7.4 + verapamil) - US
Item
2082
Protein
P-gp
Organism
Human
Assay Sub Type
Cell Based
Family:
Transporter
Organism:
Human
Construct Details:
Full Length, Recombi
Cell Type:
MDCKII
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Detection Method:
HPLC-MS
Measured Response:
Peak Area Response
Turnaround Time
Standard:
20 Business Days
Additional Information
Brand:
Cerep
Testing Location:
USA - St Charles, MO
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