OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
This panel of assays is designed to determine the stability of a test compound with each of the common human recombinant CYP isozymes in 96-well plate format. The test compound is quantified at five time points by HPLC-MS/MS analysis.
No. of Assays on Panel:
7
Assays on Panel:
Family
CYP450
Name
Intrinsic clearance (CYP1A2) - US
Item
1645
Protein
CYP1A2
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
Intrinsic clearance (CYP2C9) - US
Item
1646
Protein
CYP2C9
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
Intrinsic clearance (CYP2C19) - US
Item
1647
Protein
CYP2C19
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
Intrinsic clearance (CYP2D6) - US
Item
1648
Protein
CYP2D6
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
Intrinsic clearance (CYP3A4) - US
Item
1649
Protein
CYP3A4
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
Intrinsic clearance (CYP2C8) - US
Item
2384
Protein
CYP2C8
Organism
Human
Assay Sub Type
Enzymatic
Family
CYP450
Name
Intrinsic clearance (CYP2B6) - US
Item
2387
Protein
CYP2B6
Organism
Human
Assay Sub Type
Enzymatic
Family:
CYP450
Organism:
Human
Construct Details:
Full length, recombi
Assay Information
Assay Type:
Biochemical
Assay Sub Type:
Enzymatic
Detection Method:
HPLC-MS/MS
Measured Response:
Peak Area Response
Testing Information
Test Concentration / Dose:
Assay is performed with 4 compound concentration(s) and each concentration tested using 48 replicate
Test Sample Requirements:
Minimum for 1) Screen: 100 μl of 10 mM stock -OR- 1 to 2 mg (pre-weighed). 2) Dose Response: 250 μl of 10 mM stock -OR- 1.5 to 2 mg (pre-weighed).
Turnaround Time
Standard:
15 Business Days
Additional Information
Brand:
Cerep
Testing Location:
USA - St Charles, MO
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