GLP-1 Human Glucagon GPCR Binding Agonist Radioligand LeadHunter assay - FR
OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Evaluation of the affinity of compounds for the human GLP-1 receptor, determined in a radioligand competition binding assay.
Family:
GPCR
Sub Family:
Glucagon
Class:
Class B
Protein Name:
GLP-1
Uniprot Number:
P43220
Gene Name:
GLP1R
Gene ID:
2740
Gene Aliases:
GLP-1-R GLP-1R
Organism:
Human
Assay Information
Assay Type:
Biochemical
Assay Sub Type:
Binding
Detection Method:
Scintillation counter
Testing Information
Ligand:
[125I]GLP-1(7-36)
Ligand Kd (nM):
0.68 nM
Ligand Concentration:
1 nM
Non Specific:
Exendin 4 at 10 µM
Incubation:
90 min at RT
Test Sample Requirements:
Minimum for 1) Screen: 60 µl of 10 mM stock -OR- 1 mg (pre-weighed) for 10µM final testing. 2) Dose Response: 90 µl of 10 mM stock -OR- 1 mg (pre-weighed) for a top concentration at 10 µM.
Minimum Order Quantity:
2
Turnaround Time
Standard:
15 Business Days
Reference Compound Data
Clinical Relevance
Therapeutic Area:
Metabolic Diseases
Additional Information
Brand:
LeadHunter
Testing Location:
France - Celle L'Evescault
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