Glucagon Human Glucagon GPCR Cell Based Antagonist cAMP LeadHunter Assay - US

Background Information:

Glucagon is an important hormone involved in carbohydrate metabolism. Produced by the pancreas, it is released when the glucose level in the blood is low (hypoglycemia) and major effect of glucagon is to stimulate an increase in blood concentration of glucose. The glucagon receptor is a 62 kDa peptide that is activated by glucagon and is a member of the G-protein coupled family of receptors, coupled to Gs. Stimulation of the receptor results in activation of adenylate cyclase and increased levels of intracellular cAMP. Glucagon receptors are mainly expressed in liver and in kidney with lesser amounts found in heart, adipose tissue, spleen, thymus, adrenal glands, pancreas, cerebral cortex, and gastrointestinal tract.

cAMP Hunter™ Gs cell lines overexpress naturally Gs coupled, wild type GPCRs and are designed to detect increases in intracellular cAMP levels in response to agonist stimulation of the receptor. These cell lines are designed to be used in conjunction with the HitHunter® cAMP Assay Detection Kit.

Family:

GPCR

Sub Family:

Glucagon

Class:

Class B

Coupling:

Gs

Protein Name:

Glucagon

Uniprot Number:

P47871

Gene Name:

GCGR

Gene ID:

2642

Gene Aliases:

GGR

Accession Number:

NM_000160

Organism:

Human

Cell Type:

CHO-K1