GPR103 (QRFP) Human QRFP GPCR Cell Based Agonist Arrestin LeadHunter Assay - US

Background Information:

GPR103, also known as SP9155 and AQ27 receptor, is an orphan G-protein-coupled receptor that belongs to the δ-group of the Rhodopsin family. GPR103 expression has been found in the brain, heart, kidney, retina, and testis. GPR103 and its RFamide peptide ligand may be involved in physiological functions such as pain modulation and neuroendocrine regulation.

PathHunter β-Arrestin GPCR cell lines are engineered to co-express the ProLink™ (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two enzyme fragments. The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal. PathHunter cell lines expressing Gq-coupled receptors can also be used to detect calcium mobilization.

Family:

GPCR

Sub Family:

QRFP

Class:

Class A

Coupling:

Gq

Protein Name:

GPR103 (QRFP)

Uniprot Number:

Q96P65

Protein Aliases:

peptide P518 receptor

Gene Name:

QRFPR

Gene ID:

84109

Accession Number:

NM_198179

Organism:

Human

Cell Type:

CHO-K1