GPR109A Human Hydroxycarboxylic Acid GPCR Cell Based Antagonist Arrestin LeadHunter Assay - US

Background Information:

PathHunter β-Arrestin GPCR cell lines are engineered to co-express the ProLink™ (PK) tagged GPCR and the Enzyme Acceptor (EA) tagged β-Arrestin. Activation of the GPCR-PK induces β-Arrestin-EA recruitment, forcing complementation of the two β-galactosidase enzyme fragments (EA and PK). The resulting functional enzyme hydrolyzes substrate to generate a chemiluminescent signal.

Family:

GPCR

Sub Family:

Hydroxycarboxylic Acid

Class:

Class A

Coupling:

Gi/Go

Protein Name:

GPR109A

Uniprot Number:

Q8TDS4

Protein Aliases:

niacin receptor 1|HCA2

Gene Name:

HCAR2

Gene ID:

338442

Gene Aliases:

HCA2|HM74A|PUMAG|Puma-g|NIACR1

Accession Number:

NM_177551

Organism:

Human

Cell Type:

CHO-K1