OVERVIEW
DOCUMENTS/REFERENCES
Biological Information
Background Information:
Histamine receptors belong to the superfamily of G protein-coupled seven transmembrane proteins. G-protein-coupled receptors constitute one of the major signal transduction systems in eukaryotic cells. Coding sequences for these receptors, in those regions believed to contribute to the agonist-antagonist binding site, are strongly conserved across mammalian species. Histamine receptors are found in most peripheral tissue and within the central nervous system.
Family:
GPCR
Sub Family:
Histamine
Class:
Class A
Protein Name:
H2
Uniprot Number:
P25021
Protein Aliases:
HH2R|Gastric receptor I
Gene Name:
HRH2
Gene ID:
3274
Organism:
Human
Assay Information
Assay Type:
Functional
Assay Sub Type:
Cell Based
Functional Mode:
Agonist
Testing Information
Test Sample Requirements:
300uL of a 1000X stock based on the top or final concentration being tested
Turnaround Time
Standard:
20 Business Days
Service Scheduling Note:
Eurofins DiscoverX will make reasonable efforts to deliver screening data within (20) business days from the start date of the scheduled assay service provided that Materials and required documentation are received prior to run date.
Clinical Relevance
Adverse / Beneficial Action:
Histamine H2 receptor antagonism is used primarily in the treatment of peptic ulcers and gastroeosophageal reflux disease (GERD); reduction of gastric acid secretion may alter bioavailability and rate of absorption of some therapeutic agents.
Additional Information
Brand:
SafetyScreen
Testing Location:
USA - San Diego, CA
Questions? Contact Us
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