HDAC8 Human Histone Deacetylase (HDAC) Enzymatic LeadHunter Assay - FR

Background Information:

The acetylation state of histones is dependent on the activity of two proteins, histone acetyltransferase and histone deacetylase (HDAC), which acetylate and deacetylate histones, respectively. The human HDAC proteins are organized into classes based on their similarity to yeast HDAC proteins. Class I HDACs include HDAC1, HDAC2, HDAC3, and HDAC8, which are homologous to the yeast Rpd3 protein. Class II HDACs are similar to yeast HDA1 and include HDAC4, HDAC5, HDAC6, HDAC7, and HDAC9. Histone deacetylase inhibitors may induce apoptosis and find use as treatment for hematological malignancies.

Family:

Epigenetic

Sub Family:

Histone Deacetylase (HDAC)

Class:

Eraser

Protein Name:

HDAC8

Uniprot Number:

Q9BY41

Gene Name:

HDAC8

Gene ID:

55869

Gene Aliases:

RPD3

Accession Number:

NM_018486

Organism:

Human

Construct Details:

Recombinant